Мікробіоценоз шкіри у хворих на червоний плескатий лишай

At the present stage, lichen planus is a fairly common skin disease. Its specific gravity in the structure of dermatoses ranges within 1—2 %. The etiological and pathogenetic factors of lichen planus remain poorly understood. In recent years, considerable attention has been paid to the study of skin microbiocenosis in patients with this dermatosis. At the same time, despite numerous studies devoted to the research of microbial landscape of the skin in patients with lichen planus, a number of aspects of the composition of microbial associations in foci of skin lesions in various clinical forms of this dermatosis remain unclear. Objective — to study the features of skin microbiocenosis in patients with various clinical forms of lichen planus and to determine its significance for the development of this dermatosis.Materials and methods. Under our observation, there were 52 patients with lichen planus (29 men and 23 women) aged 19 to 43 years. 29 of them were diagnosed with the classic clinical form of dermatosis, 12 with hypertrophic and 11 with pigmented form. In 11 patients with the classic clinical form of lichen planus, a limited pathological process was identified, and in the rest (41 patients) with various clinical forms of dermatosis, a widespread nature of the lesion was identified. The control group consisted of 30 healthy individuals comparable by sex and age. Bacteriological examination of the skin microflora from the lesions was carried out in all patients who were under observation. Results and discussion. In patients with both limited and widespread classic lichen planus, biinfection of lesions with the obligate presence of S. aureus in the microbial associations and sporadic presence of Str. pyogenes, S. epidermidis, S. saprophyticus, E. coli and «other microorganisms» were observed. In patients with hypertrophic and pigmented forms of dermatosis, an expansion of the spectrum of infectious agents, that is, the development of polyinfection was detected. Conclusions. In patients with both limited and widespread classic lichen planus, biinfection of lesions with obligate presence of S. aureus in the microbial associations, facultative presence of S. epidermidis, Str. pyogenes, S. saprophyticus, episodic participation of «other microorganisms» (Micrococcus, Bacillus, Sarcina) and the appearance of E. coli were established.In hypertrophic and pigmented clinical forms of lichen planus, we established the branching of the spectrum of microbial associations in the form of the development of polyinfection due to a distinct increase in the specific weight of the «other microorganisms».The results of the study of the microbiocenosis of the skin in patients with lichen planus should be taken into account when developing tactics for the rational therapy of this dermatosis.