The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is an aggressive form of dedifferentiated thyroid cancer responsible for approximately 40% of thyroid cancer-related deaths. Thyroid hormone receptor beta (TRβ), a nuclear hormone receptor, serves as a tumor suppressor in thyroid cancers and is downregulated in ATC. Lysine-specific demethylase 1 (LSD1), a potential TRβ binding partner, is upregulated in ATC and acts as a tumor promoter. These findings enable the visualization of TRβ and LSD1 colocalization in thyroid cell lines through immunofluorescence and suggest how manipulating their interactions could offer new therapeutic options for ATC patients.

Publication Details

Journal
ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Published
2025-06-02
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Hemophilia Treatment and Research
article

The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer

article en

Abstract

Anaplastic thyroid cancer (ATC) is an aggressive form of dedifferentiated thyroid cancer responsible for approximately 40% of thyroid cancer-related deaths. Thyroid hormone receptor beta (TRβ), a nuclear hormone receptor, serves as a tumor suppressor in thyroid cancers and is downregulated in ATC. Lysine-specific demethylase 1 (LSD1), a potential TRβ binding partner, is upregulated in ATC and acts as a tumor promoter. These findings enable the visualization of TRβ and LSD1 colocalization in thyroid cell lines through immunofluorescence and suggest how manipulating their interactions could offer new therapeutic options for ATC patients.

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Good health and well-being
Openalex Percentile: Top 34%
Hemophilia Treatment and Research
OpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) (2025) | TGRS Research Map | TGRS