A Qualitative Exploration of Emotional Experiences in Patients with Thin Endometrium Undergoing Repeated Cancellations of Frozen-Thawed Embryo Transfer Cycles

Qun Wei, Xia Hong, Yu He, Meiling Xu, Xuechun Jiang, Xuling Shen, Zilian Wang Reproductive Medicine Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, People’s Republic of ChinaCorrespondence: Zilian Wang, Email [email protected]: The aim of this study was to investigate the emotional experience of patients with thin endometrium (TE) who have repeatedly cancelled their cycles due to unsuitability for embryo implantation during the endometrial preparation phase of freeze-thaw embryo transfer (FET). The overall aim is to improve management strategies and quality of life for these patients.Methods: A descriptive phenomenological methodology was utilized to conduct in-depth, semi-structured interviews with ten patients diagnosed with TE who had experienced repeated FET cancellations between January and June 2024. The emotional responses elicited were systematically analyzed to identify core themes.Results: Four primary themes emerged: 1) a spectrum of negative emotional responses; 2) deterioration in marital relationships; 3) a pronounced need for professional support, including a) expanded treatment options and b) informational guidance; and 4) diverse coping mechanisms employed by patients.Conclusion: Healthcare providers must recognize and address the complex emotional responses associated with repeated transfer cancellations in patients with TE. Tailored psychological interventions and comprehensive support services may not only foster emotional well-being but also potentially improve clinical outcomes in assisted reproductive technology (ART) settings.Keywords: thin endometrium, frozen-thawed embryo transfer, patient experience, qualitative research, emotional distress