Potential applications for human hypoxia models

The thesis is structured to methodically explore the complex and multifaceted role of hypoxia in human biology, focusing on implications for disease, potential measures to enhance human performance in hypoxia, and potential applications of human hypoxia models in drug development. Central to all these investigations are highly standardized human hypoxia models. The significance of this research is highlighted by the 2019 Nobel Prize for the discovery of the HIF gene, a crucial regulator in oxygen sensing. Additionally, the thesis covers the interaction between the body’s hypoxia-sensing pathways and circadian rhythms, a connection highlighted by the work of Adamovich et al. and further supported by our findings in humans. This expands upon the foundational discoveries recognized by the 2017 Nobel Prize for the discovery of the clock gene. Unique animal models, such as the naked mole rat, informed the development of human hypoxia models. The thesis examined how elevated carbon dioxide (CO2) levels might improve oxygenation during air travel and explored the effects of hypoxia on cognitive, metabolic, and circadian responses.<br>