Prevalence and Associated Factors of Paroxysmal Atrial Fibrillation and Atrial Arrhythmias During Hospitalizations for Exacerbation of COPD

Hieu Lan Nguyen,1,2 Thang Duy Nguyen,1,2 Phuong Thu Phan3,4 1Cardiovascular Department, Hanoi Medical University, Hanoi City, Vietnam; 2Cardiovascular Center, Hanoi Medical University Hospital, Hanoi City, Vietnam; 3Internal Medicine Department, Hanoi Medical University, Hanoi City, Vietnam; 4Respiratory Center, Bach Mai Hospital, Hanoi City, VietnamCorrespondence: Thang Duy Nguyen, Cardiovascular Department, Hanoi Medical University, Hanoi City, Vietnam, Tel +84 989 631 112, Fax +84 24 3574 6298, Email [email protected]: This study aimed to investigate the proportion and risk factors of paroxysmal atrial fibrillation (AF) and atrial arrhythmias (AA) in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in Vietnam.Patients and Methods: A prospective observational study was conducted at two major hospitals in Hanoi, Vietnam, from January 2022 to January 2023. A total of 197 AECOPD patients were recruited. ECG and 24-hour Holter ECG were used to diagnose paroxysmal AF and AA.Results: The prevalence of paroxysmal AF and AA were 15.2% and 72.6%, respectively. Factors associated with a higher likelihood of paroxysmal AF included aging 75 years old and above (aOR = 3.15; 95% CI: 1.28 to 8.48), Premature atrial complex (PAC) with 500 or more (aOR = 3.81; 95% CI: 1.48 to 10.97) and severity of COPD as group C and D (aOR = 3.41; 95% CI: 1.28 to 10.50). For AA, aging 75 years old and above (aOR = 2.25; 95% CI: 1.28 to 5.20), smoking (aOR = 2.10; 95% CI: 1.07 to 4.23) and P wave dispersion (PWD) with 40 milliseconds or more (aOR = 3.04; 95% CI: 1.54 to 6.19) were associated with a higher likelihood of AA.Conclusion: Overall, our findings highlight the associated factors with the paroxysmal AF and AA among AECOPD patients. This underscores the importance of a multifaceted approach to risk assessment and management in this vulnerable population, focusing not only on respiratory symptoms but also on comprehensive cardiovascular evaluation and intervention.Keywords: chronic obstructive pulmonary disease, atrial fibrillation, atrial arrhythmias, P wave dispersion, associated factor