An outcome analysis of 44 necrotizing fasciitis patients in a single center

Objective: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with high mortality, requiring prompt diagnosis and surgical intervention. We have investigated the outcomes of NF patients in our center. Patients and Methods: This retrospective study analyzed 44 patients diagnosed with NF. The study aimed to explore the microbial etiology, predisposing factors, management strategies, The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scores and their relationship to mortality. Radiological studies, including CT, MRI, and ultrasound, were used to confirm the diagnosis, followed by surgical debridement and appropriate antibiotic therapy. Results: The most common pathogen was Escherichia coli (26.9%), with diabetes mellitus (DM) being the most frequent comorbidity (75%). The mean age of patients was 54.6 years, and the overall mortality rate was 27.3%. Elevated HbA1c levels and delayed surgical intervention were associated with higher mortality. However, neither LRINEC score nor the location of the infection had a significant impact on outcomes. Early debridement and control of infection were crucial for survival, particularly in patients with DM and high HbA1c. Conclusion: Our findings support the importance of early intervention and management in reducing mortality from NF. The study highlights the need for timely surgical debridement and careful management of comorbid conditions, particularly diabetes, in improving patient outcomes.