Natural Modulators of Key Signaling Pathways in Skin Inflammageing

Qianqian Ren,1 Liping Qu,2 Yonglei Yuan,3 Feifei Wang2 1Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, 650106, People’s Republic of China; 2Yunnan Characteristic Plant Extraction Laboratory, Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd., Kunming, 650106, People’s Republic of China; 3Botanee Research Institute, Shanghai Jiyan Bio-Pharmaceutical Development Co., Ltd., Shanghai, 201702, People’s Republic of ChinaCorrespondence: Feifei Wang, Research and Development Center, Yunnan Botanee Bio-Technology Group Co. Ltd., No. 999 huaxu Road, Shanghai, 201702, People’s Republic of China, Tel +86 21 39880807, Email [email protected]: Low-grade chronic inflammation without obvious infection is defined as “inflammageing” and a key driver of skin ageing. Although the importance of modulating inflammageing for treating skin diseases and restoring cutaneous homeostasis is increasingly being recognized. However, the mechanisms underlying skin inflammageing, particularly those associated with natural treatments, have not been systematically elucidated. This review explores the signaling pathways associated with skin inflammageing, as well as the natural plants and compounds that directly or indirectly target these pathways. Nine signaling pathways and 60 plants/constituents related to skin anti-inflammageing are discussed, exploring plant mechanisms to mitigate skin inflammageing. Common natural plants with anti-inflammageing activity are detailed by active ingredients, mechanisms, therapeutic potential, and quantitative effects on skin inflammageing modulation. This review strengthens our understanding of these botanical ingredients as natural interventions against skin inflammageing and provides directions for future research.Keywords: cutaneous homeostasis, inflammageing, plant extract, skin ageing