Magnetic Actuation Chamber System (MACS)

The Magnetic Actuation Chamber System (MACS) is an innovative solution designed to enhance the cultivation of cells and tissues under simulated microgravity conditions using a 3D clinostat. By integrating a magnetic actuator with a microfluidic organ-on-chip platform, the system facilitates precise mechanical stimuli for tissue engineering and disease modeling. Key upgrades, including a pneumatic piston system, Raspberry Pi 4-based processing, and enhanced nutrient delivery through microfluidic pumps, significantly improve reliability, data collection, and adaptability. The system’s modular design ensures flexibility for future modifications. Initial results demonstrate the potential of MACS to replicate natural cellular environments, with plans to study heart and lung cell growth under simulated conditions. This research aims to explore cellular behavior in microgravity, with potential applications in cancer treatment and regenerative medicine. The MACS represents a critical advancement in biotechnological research, providing insights into cell growth mechanisms and supporting novel therapeutic discoveries.