Itraconazole effect on growth and development of Aspergillus, Beauveria fungi

The study examined the effect of itraconazole on the fungal cultures Beauveria Bassiana and Aspergillus awamori by adding a colloidal solution of the drug to the nutrient medium. It was found that itraconazole actively inhibits the growth of fungal cultures, causing multiple morphological changes. When the drug was added to Petri dishes at a concentration of 0.25 mg, 0.5 mg, 1.0 mg, a decrease in the number of colonies relative to the control samples was observed by 83.00%, 96.50% and 99.00%, respectively, for Beauveria Bassiana; and by 94.90%, 96.95%, 97.97% for Aspergillus awamori. The average deviation in the effect of itraconazole on various taxa was 29.42%. The average experimental growth dynamics for Beauveria Bassiana corresponded to – 0.67 colonies/day (control – 20 colonies/day); Aspergillus awamori – 1.43 colonies/day (control – 19.7 colonies/day).