The Correlation Between a Methylenetetrahydrofolate Reductase Deficiency in Autism Spectrum Disorder Patients and The Presence of Mental Health Disorders

• Currently little literature exists on connection between Methylenetetrahydrofolate reductase (MTHFR) deficiency and mental health disorders • Reduced enzyme activity associated with certain MTHFR variants contributes to altered folate metabolism, elevated homocysteine levels, and disrupted DNA methylation, all of which are implicated in mental health disorders • Identifying genetic risk factors could facilitate earlier diagnosis and intervention, leading to improved outcomes • Relevant results could help reduce stigma and promote greater understanding of challenges faced by patients on the spectrum