Аналіз етіопатогенетичних чинників формування і перебігу хронічного панкреатиту залежно від віку пацієнтів

Chronic pancreatitis (CP) is a significant medical condition. The determination of the key etiopathogenetic factors depending on age will improve the prevention, diagnosis and treatment of this disease. The objective: to assess the significance of etiopathogenetic factors of CP course in different age groups of patients. Materials and methods. 341 patients with CP in remission were examined, the average age of the patients was 58.17±2.46 years. The study was conducted on the basis of the communal non-commercial enterprise “Odessa Regional Clinical Medical Center” and the communal non-commercial enterprise “Ternopil Municipal City Hospital No. 2” with the analysis of anamnestic, anthropometric, clinical and biochemical data for the period 2015–2023. The study participants were divided into three groups: I group – 129 patients under 45 years, II group – 114 patients aged 46–65 years, III group – 98 patients over 66 years old. Statistical analysis was performed in accordance with state standards and guidelines for medical and biological statistics using Excel and the statistical package Statistica 8.0. Results. In patients under 45 years of age gastroduodenogenic (86.8%), alcoholic (75.9%) and biliary (53.5%) factors prevailed. Mixed factors were determined in 63.5% of cases. In patients aged 46–65 years the main factors were dyslipidemia (67.5%), biliary pathology (67.4%) and metabolic disorders (46.5%), with mixed etiopathogenesis in 88.6% of cases. In patients aged 65 years the ischemic (87.7%), gastroduodenogenic (84.7%) and dyslipidemic (77.7%) factors dominated, mixed factors were found in 96.9% of patients. Conclusions. Taking into account age-related etiopathogenetic factors is important for development of effective CP treatment programs.