In Vivo Study on the Evaluation of a Sleeping Mask Gel Containing Red Cotton Tree Flower (Bombax ceiba L.) Extract

The red cotton tree flower (Bombax ceiba L.) is a local plant commonly found in Northern Thailand. It is used in Northern Thai cuisine and traditional Thai medicine. A previous study demonstrated the antioxidant properties of red cotton tree flowers in a formulated skincare product, specifically a sleeping mask gel. This study aimed to develop an anti-wrinkle facial skincare product containing red cotton tree flower extract. The flowers were extracted using 99% ethanol through maceration at room temperature. A 1.5% concentration of the extract was incorporated into the sleeping mask gel. An in vivo study was conducted to evaluate skin irritation and anti-wrinkle efficacy. Twenty volunteers aged 30–60 years (7 men and 13 women) participated in the study. The results showed no skin irritation among the volunteers, and the product effectively reduced wrinkles after one month of use. Additionally, it increased skin moisture within the first week of application. The volunteers expressed overall satisfaction with the product and reported no adverse reactions. This newly developed product not only highlights the effectiveness of red cotton tree flower extract but also demonstrates its commercial potential.