In vivo photopharmacological inhibition of hippocampal activity via multimodal probes - perspective and opening steps on experimental and computational challenges

Acknowledgements: The authors acknowledge Prof Stefan Hecht, Dr Michael Pätzel and Jutta Schwarz for reproducing the synthesis to provide photodrug 1. 3D data on the vascular system in the rat brain were kindly provided by Prof Hyung Joon Cho. The authors acknowledge Dr Dominik Marti for co-developing and maintaining MCmatlab. Furthermore, J.G. thanks Prof. Emil List-Kratochvil for the support and fruitful discussion, in particular, at the beginning of the project. J.G.'s special gratitude goes to Prof. Alexander Böker at the University of Potsdama and Fraunhofer IAPc, who gave space and support needed to work on his scientific vision as a Junior Group Leader. J.G. acknowledges the support from the German Research Foundation (Deutsche Forschungsgemeinschaft DFG via Research Fellowships Gz. GU 2073/1-1). A.C.L. acknowledges Welcome Trust for a Junior Interdisciplinary Fellowship. T.E.N. acknowledges funding from EPSRC Cambridge NanoDTC (EP/L015978/1). This work was funded by the EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers, EP/S009000/1. We gratefully acknowledge the fruitful discussions with the members of the Bioelectronics Laboratoryb.