Treatment Approaches, Risk Factors, and Perinatal Outcomes in Pregnancy Complicated by Nephrolithiasis: A Single-Center Retrospective Study

Xian Chen,* Rui-Lan Ni,* Bing-Qing Lv Department of Gynecology and Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bing-Qing Lv, Department of Gynecology and Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, 350000, People’s Republic of China, Tel +86 18950330039, Email [email protected]: Nephrolithiasis is a common non-obstetric cause of abdominal pain during pregnancy. This study aimed to investigate various treatment approaches for nephrolithiasis during pregnancy, identify the associated risk factors, and evaluate perinatal outcomes.Methods: A retrospective analysis was conducted on the clinical treatment of 208 patients diagnosed with nephrolithiasis during pregnancy, admitted to Fujian Maternal and Child Health Hospital, China, between January 2020 and December 2023. Data on maternal demographic characteristics were extracted to analyze the risk factors associated with nephrolithiasis in pregnancy and to explore correlations with specific treatment modalities through Chi-squared test, Fisher’s exact probability method, and univariate logistic regression analysis.Results: The study included 208 patients, of whom 130 were managed with observation, 46 patients received symptomatic treatment with appropriate medications, and 32 patients underwent surgical intervention, specifically ureteral stent placement. Statistical analysis identified that the timing of symptom onset, presence of clinical symptoms, dilatation of ureter, location of dilation, stone size, and abnormalities in routine urine tests were significant risk factors influencing treatment modalities for nephrolithiasis in pregnancy. A statistically significant difference was observed in treatment modalities among patients with nephrolithiasis complicated by hypertensive disorders. In contrast, patients with combined hyperglycemic disorders exhibited no statistically significant difference among the different treatment modalities.Conclusion: Effective and timely management of nephrolithiasis in pregnancy, guided by patient-specific clinical characteristics, is essential for optimizing maternal and perinatal outcomes.Keywords: abnormal routine urine test, perinatal outcomes, pregnancy complicated by nephrolithiasis, risk factors, treatment modalities