REV1 regulation of DNA damage response in the G2/M phase of the cell cycle

The S phase of the cell cycle engages in DNA replication. It’s prone to DNA damage from their deprotected nature, triggering DNA damage responses (DDRs). Typically, damage results in arrest, allowing the DDR pathway to engage in either repair or bypass damage to promote survival and integrity. For DNA damage bypass, low-fidelity polymerases orchestrate error-prone DNA synthesis, resulting in mutagenic nucleotide pairing. Here, REV1 is the principal scaffolding molecule that recruits other polymerases to the site of damage by protein-protein interactions. We hypothesized that REV1 may play an essential novel role in regulating the cell cycle.