Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review

Jingya Wang,1,2,* Kang Yan,3,* Leilei Ma,1,4,* Xianglei Yan,1 Zihan Meng,1 Ji-an Li,1 Meng Wang,1 Chenguang Du,1 Yueyue Yu1 1College of Traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, People’s Republic of China; 2Baoding No. 1 hospital of Traditional Chinese Medicine, Baoding, Hebei, People’s Republic of China; 3College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, People’s Republic of China; 4School of Public Health, North China University of Science and Technology, Tangshan, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueyue Yu; Kang Yan, Email [email protected]; [email protected]: Asthma is a respiratory disease common among all age groups, and there is currently no cure that can be applied, as the patients react differently to the available treatments. Recent studies have shown that the Notch signaling pathway can regulate the dynamic balance between Th1 and Th2 cells, inhibit airway inflammation, reduce airway hyperresponsiveness and remodeling, and promote mesenchymal stem cell (MSCs) homing. This study conducted a comprehensive search of multiple large databases and provided a narrative review of the role of the Notch signaling pathway in asthma.Keywords: bronchial asthma, notch pathway, remodeling, inflammation, hyperresponsiveness