Immune Response to Long-Term Lipopolysaccharide Infusion in Sheep

Poor maternal nutrition (restricted and over-feeding) during gestation alters metabolism, growth, and body composition of offspring. It may also affect immune function. The purpose of this study is to determine the safety and efficacy of long-term immune challenge using lipopolysaccharide in sheep. Through two challenge weeks, each consisting of five days of lipopolysaccharide treatment, monitoring, and data collection, the treatment was found to be safe in sheep and effective to elicit an immune response. The data from this study will inform future studies on maternal nutrition in the University of Connecticut Animal Science Department.