The effect of twelve weeks of high-intensity functional training and Ginkgo biloba consumption on the serum levels of some inflammatory cytokines in operational male firefighters of Yazd city

Introduction: functional exercises and consumption of the medicinal plant Ginkgo biloba, a natural source of flavonoids and polyphenolic compounds, have beneficial effects in improving the inflammatory state and physical performance of people exposed to occupational stress. Therefore, the aim of the present study was to investigate the effect of 12 weeks of high-intensity functional training and consumption of Ginkgo biloba extract on the serum levels of interleukin-8 and interleukin-1β in operational male firefighters of Yazd city. Materials and Methods: For this purpose, 48 male firefighters were randomly divided into four groups including high-intensity functional training (HIFT), high-intensity functional training with ginkgo biloba consumption, ginkgo biloba extract consumption, and control-placebo. The training was carried out for 12 weeks and 4 sessions per week. Ginkgo biloba extract (80 mg) was administered as two capsules once a day after breakfast for 12 weeks. Blood samples were taken before and 48 hours after the last training session. Data were analyzed using two-way analysis of variance with SPSS-26 software. Results: The results showed that the interaction effect of exercise and ginkgo biloba extract, as well as the effect of exercise and ginkgo biloba extract alone, caused a significant decrease in the serum levels of interleukin-8 and interleukin-1β (p<0.05). The highest percentage of changes in interleukin-8 and interleukin-1β were obtained following exercise intervention along with the consumption of Ginkgo biloba extract. Conclusion: Performing high-intensity functional exercises with Ginkgo biloba extract had the greatest effect in reducing serum levels of inflammatory indicators and improving oxidative stress conditions in firefighters.