Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Wenting Xu,1 Yanxing Huang,2 Ping Ji,2 Jiayu Wang,2 Jinfen Yu,2 Li Yang2 1Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China; 2Department of Obstetrics and Gynaecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of ChinaCorrespondence: Li Yang; Jinfen Yu, Email [email protected]; [email protected]: Failure to resolve inflammation is a novel feature of angiogenic-dependent diseases such as endometriosis and atherosclerosis.The correlation and causality between endometriosis and coronary heart disease is unclear. Here, we investigated the correlation and causality between endometriosis and coronary heart disease.Methods: The relevant data was extracted from the NHANES database (Year range: 1999– 2006) and analyzed to determine the correlation between endometriosis and coronary heart disease using weighted multivariable logistic regression models. Mendelian randomization analysis was used to assess the causal relationship between endometriosis and coronary heart disease risk.Results: We evaluated the data obtained from 3943 participants and did not observe any association between endometriosis and coronary heart disease in weighted multivariable logistic regression models (Model 1, OR: 1.85, 95% CI: 0.66– 5.15, P: 0.23; Model 2, OR: 0.89, 95% CI: 0.30– 2.62, P: 0.82; Model 3, OR: 0.61, 95% CI: 0.19– 1.95, P: 0.38). Two-sample Mendelian randomization analysis did not reveal a causal relationship between endometriosis and coronary heart disease (OR: 1.00, 95% CI: 0.94– 1.07, P: 0.882).Conclusion: Our findings did not indicate any association or causal relationship between endometriosis and coronary heart disease. Keywords: endometriosis, coronary heart disease, cross-sectional study, NHANES, Mendelian randomization