Association Between Time in Range and Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients with Hypoglycemia Unawareness: A Single‐center Retrospective Study

Chi Xu,1,2 Wu Dai,1 Yan Liu,1 Rong Zhang,1 Erlan Shi,1 Xiangxiang Shan,1 Yonghong Cao1,2 1Department of Endocrinology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People’s Hospital), Hefei, 230011, People’s Republic of China; 2The Fifth Clinical Medical College, Anhui Medical University, Hefei, 230032, People’s Republic of ChinaCorrespondence: Yonghong Cao, Department of Endocrinology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People’s Hospital), Hefei, 230011, People’s Republic of China, Email [email protected]: Our study aimed to investigate the association between time in range (TIR) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients with hypoglycemia unawareness.Methods: This is a retrospective cross-sectional study. In our study, 298 T2DM patients with hypoglycemia unawareness were recruited from the Department of Endocrinology, Hefei Second People’s Hospital from 01/09/2020 to 30/06/2023. Patients were divided into DR group (97 cases) and non-DR group (NDR, 201 cases). We compared the clinical data and blood glucose fluctuation indexes of the two groups. Meanwhile, we also observed these indicators, especially the prevalence of DR and the time below range (TBR) in groups with different TIR levels (Q1 group: TIR≤ 70%, 79 cases; Q2 group: 70%