Akut İskemik İnme Tedavisinde Sadece İntra-Arteriyel tPA ile Sadece İntravenöz tPA'nın Karşılaştırılması

Aim: The method and timing of administration of tissue plasminogen activator (tPA) in the treatment of acute ischemic stroke (AIS) remain unclear. In our study, we aimed to compare the effectiveness of intra-arterial (IA)-tPA compared to intra-venous (IV)-tPA in AIS. Material and Methods: Patients with AIS received IV-tPA within one hundred and eight minutes or IA-tPA within the first six hours. Before both treatments, their conditions were evaluated and treatments were performed. AIS patients were divided into those receiving IV alteplase (maximum 0.90 mg/kg) and those receiving IA alteplase (maximum 0.30 mg/kg). Demographic characteristics, systemic diseases and clinical outcomes were evaluated in both groups. Results: It was observed that the clinical findings of the patients in the IA group were worse at the time of admission, but were better than those in the IV group after the procedure. While the ICH rate was similar in both groups (p>0.817); the recanalization rate was higher in the IA group compared to the IV group (p