Дослідження з розробки методик контролю якості твердого мила для терапії псоріазу

Products in the form of soap are a relevant addition to the complex therapy of dermatological diseases, includingpsoriasis. The skin affected by psoriasis requires “soft” care, so the use of a hygienic product that has a moisturizingand exfoliating effect will have a positive impact on the course of the disease, complementing the effect of the maintherapeutic agents. In view of this, based on the results of previous studies, we have proposed three compositionsof solid soaps, for which it is advisable to conduct a study of the main quality indicators at this stage of development.Aim. To develop the quality control methods for model samples of the solid soap obtained.Materials and methods. The study materials were model samples of the solid soap containing palm kernel, coconut, avocado, almond, olive, castor oils, as well as citric, salicylic acid and lactobionic acid. The study of organolepticproperties, solubility, as well as characteristics affecting the soap quality (pH, chlorides and other substances insolublein ethanol, hydroxides of free fatty acids or alkali metals, the fatty acid content), such parameters as “Acid number” and“Iodine number” was carried out. The active ingredients were identified.Results. The resulting soaps are solid to the touch, without deformations, cracks and mechanical inclusions, whiteor slightly yellowish in color, odorless or with a peculiar smell. They are soluble in water and ethanol (96 %) and havea pH in the range from of 6.5 to 8.5. When determining the content of chlorides and other substances insoluble in ethanol, the residue weight was not more than 0.15 g in all samples studied. When determining the content of hydroxides of freefatty acids or alkali metals, no more than 0.8 ml of 0.1 M sodium hydroxide solution was used for titration. The contentof fatty acids was more than 40 %; the acid number was no more than 205; the iodine number was not less than 83.The results of identification reactions were positive.Conclusions. The results of the study indicate compliance with the requirements for the main quality indicators ofthe solid soap samples proposed by us.