Longitudinal Evaluation of the HABC Monitor Among Trauma Survivors

Abdelfattah Alhader,1– 3 Anthony Perkins,4 Patrick O Monahan,2 Ben L Zarzaur,5 Cristina Barboi,6 Malaz A Boustani2,3 1Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan; 2Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; 3Center for Health Innovation and Implementation Science, Indiana University School of Medicine, Indianapolis, Indiana, USA; 4Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA; 5Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; 6Department of Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana, USACorrespondence: Abdelfattah Alhader, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA, Tel +1 317 274 8536, Email [email protected]: To examine the sensitivity to change of the Healthy Aging Brain Care Monitor (HABC-M) through a longitudinal analytical comparison with reference standards.Patients and Methods: We used longitudinal data from 120 participants in a multicenter randomized controlled trial evaluating the effectiveness of the Trauma Medical Home (TMH). We used the following reference standards: The depression and anxiety subdomains of the Hospital Anxiety and Depression Scale (HADS), the Patient-Reported Outcomes Measurement Information System Sleep Disturbance Short Form 4a (PROMIS-SF), and the Pain, Enjoyment of Life, and General Activity Scale (PEG). We assessed sensitivity to change using three longitudinal comparative analytical methods. The correlation of the HABC-M score with reference standards’ scores over time, the correlation of changes in the HABC-M score with changes in reference standards’ scores, and a longitudinal analysis to compare changes in the HABC-M against reference standards’ known change categories.Results: Throughout the six-month period, the HABC-M exhibited moderate to high correlations with the HADS (r = 0.66, p< 0.001 for the depression subdomain and r = 0.42, p< 0.001 for the anxiety subdomain), the PROMIS-SF (r = 0.57, p< 0.001), and the PEG (r = 0.47, p< 0.001). The changes in HABC-M significantly correlated with changes in reference standards at various time points. HABC-M scores were significantly different across known change categories established by the four reference standards, with standardized response mean (SRM) values ranging from 1.08 to 1.44.Conclusion: The HABC-M is capable of monitoring the recovery of older trauma survivors.Keywords: sensitivity to change, analytical comparison