Comparative Characteristics of Standard and Combined Therapy (With Using Human Urinary Callidinogenase) in Patients with Cerebral Infarction

Acute brain infarction (ABI) is caused by a sharp decrease in blood and oxygen supply [3.6]. Stroke is one of the main health problems of the adult population and ranks third among the causes of death in developed countries. [1.10] 31%of stroke patients require external assistance to care for themselves, and 20% cannot walk independently. Only about 20% of patients can return to their old jobs. Stroke places special obligations on the patient's family members and places a heavy social and economic burden on society.Ischemic stroke is caused by hypertension, diabetes, heart disease, age, heredity, and other risk factors.[2] This leads to stenosis and occlusion of the brain vessels, as well as to decrease or disruption of the blood supply to the brain's nerve cells; thus, hypoxic-ischemic necrosis occurs. Inflammation in the early stages after cerebral infarction is one of the important mechanisms of neural damage in the areas of infarction and semi-shadow [1,3].KLK is a group of serine proteases present in most tissues and fluids of the body, including plasma calcreine (PK) and tissue calcreine (TK). Tissue calcreine is found in the tissues of the lungs, kidneys, blood vessels, brain and adrenal glands and plays a key role in the regulation of blood microcirculation, blood pressure and blood flow; it is a necessary component for maintaining homeostasis and a factor of disease response, and also responsible for the production of kinins (bradykinin and callidin), which contribute to local vascularization and prolonged vascularization, as well as specifically enhance blood flow in vascular tissues by increasing the level.Human urinary kallidinogenase -is a selective cerebrovascular dilator which relaxes blood vessels and improves the aerobic level of brain tissue. Edaravon in combination with urinary kallidinogenase affects many stages of ischemic stroke. Combined therapy of ischemic stroke in the acute period demonstrates a significant improvement in neurological status and contributes to adosed reduction and stabilization of blood pressure compared to standard therapy.