Clinical effect of Yishen Huashi Granules combined with conventional Western medicine on stage 2-4 chronic kidney disease

ObjectiveTo investigate the clinical efficacy of Yishen Huashi Granules combined with conventional Western medicine in the treatment of stage 2-4 chronic kidney disease （CKD） and its influence on microinflammation.MethodsA total of 88 patients with stage 2-4 chronic kidney disease （CKD） who were treated at Wuhan Fifth Hospital from December 2020 to May 2022 were selected and randomly divided into the control group （44 cases） and observation group （44 cases） according to random number table method. Patients in both groups were given conventional Western medicine treatment， and those in the observation group were additionally given Yishen Huashi Granules. Interventions were performed for 12 weeks. The clinical efficacy， and changes in the blood biochemical indexes total serum protein （TP）， serum Albumin （Alb）， serum creatinine （Scr）， blood urea nitrogen （BUN）， estimated glomerular filtration rate （eGFR）， β2-microglobulin （β2-MG）and microinflammatory indexes ［（white blood cell count （WBC）， lymphocyte count （LYM）， percentage of lymphocytes （LYM%）， neutrophil count （NEUT）， percentage of neutrophils （NEUT%）， neutrophil /lymphocyte ratio （NLR）， hypersensitive C-reactive protein （hs-CRP）， interleukin-6 （IL-6）］ before and after treatment were compared. Meanwhile， patients in both groups were subgrouped into stage G2-3a and stage G3b-4 subgroups based on the eGFR. Changes in renal function indicators （Scr， BUN， eGFR， β2-MG） before and after treatment were compared.ResultsAfter treatment， the total effective rate was significantly higher in the observation group than the control group （81.82% vs. 61.36%， <italic>P</italic>&lt;0.05）. Post-treatment Hb ［（134.13±20.87） vs （129.62±22.19） g/L］， Alb ［（43.97±4.71） vs （40.63±4.97） g/L］and TP［（73.53±5.93） vs （71.93±7.15） g/L］ were significantly higher than pre-treatment values in the observation group （<italic>P</italic>&lt;0.05）， and their improvements were superior than the control group （<italic>P</italic>&lt;0.05）. Renal function indexes were significantly improved after treatment in both groups， and eGFR were significantly higher in the observation group than the control group （<italic>P</italic>&lt;0.05）. Scr， BUN and β2-MG were significantly lower in the observation group than the control group （<italic>P</italic>&lt;0.05）. Subgroup analyses showed that renal function indexes were significantly improved after treatment in G2-3a and G3b-4 subgroups （<italic>P</italic>&lt;0.05）， and their improvements were superior than the control group （<italic>P</italic>&lt;0.05）. . NEUT， IL-6， WBC， hs-CRP and NLR were significantly reduced， and LYM was significantly elevated after treatment in the observation group （<italic>P</italic>&lt;0.05）， and their improvements were superior than the control group （<italic>P</italic>&lt;0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （<italic>P</italic>&gt;0.05）.ConclusionYishen Huashi Granules combined with traditional Western medicine can effectively improve clinical efficacy， and it is also effective in patients with moderate-to-severe renal insufficiency. The mechanism of action may be related to inhibiting microinflammatory response in vivo， improving nutritional status， protecting renal function and delaying the progression of CKD.