Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study

Fei Liu,1,&ast; Tianqing Cao,1,&ast; Yacong Liu,1 Dian Huang,2 Jingxin Zhang3 1Department of Cardiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Department of Radiology, Affiliated hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of China; 3Department of General Surgery, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212002, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jingxin Zhang, Email [email protected]: The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).Methods: The study included liver cirrhosis patients aged 18– 75 from Northern Jiangsu People’s Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.Results: The study found that the onset of CCM was not related to the etiology of inducing cirrhosis. Pittsburgh Sleep Quality Index (PSQI) score (odds ratio (OR) = 13.476, 95% confidence interval (CI) = 1.514– 119.923, P = 0.020), absolute GLS (OR = 0.328, 95% CI = 0.210– 0.510, P < 0.001), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR = 1.050, 95% CI = 1.025– 1.076, P < 0.001) were identified as independent risk factors for inducing CCM.Conclusion: In patients with CCM, a decrease in sleep quality often occurs. When cirrhotic patients also have poor sleep quality, along with a decrease in absolute Global Left Ventricular Strain (GLS) levels and an increase in NT-proBNP levels, these factors may pose a higher risk for CCM development. However, further validation of these research findings is required in larger sample sizes.Keywords: cardiomyopathy, liver cirrhosis, sleep quality, cirrhotic cardiomyopathy