Abundance and viability of bryophyte spores found in honeybee pollen

Chronic toxoplasmosis, a foodborne illness primarily affecting immunocompromised people and pregnant women, remains untreatable. The causative parasite, Toxoplasma gondii, survives via tissue cysts within brain cells. To investigate nutrient acquisition by T. gondii in cyst development, the translocon-encoding genes GRA17 and GRA23 are proposed as possible drug targets, because they facilitate material transfer between host and parasite. The roles of GRA17 and GRA23 have been analyzed through physiological differences between knockout strains in growth and plaque assays. Preliminary results indicate both genes are crucial for parasite growth, suggesting that targeting them may be an effective strategy to treat chronic toxoplasmosis.

Publication Details

Journal
ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Published
2025-06-02
Primary Topic
Toxoplasma gondii Research Studies
Type
article
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article

Abundance and viability of bryophyte spores found in honeybee pollen

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Toxoplasma gondii Research Studies
article

Abundance and viability of bryophyte spores found in honeybee pollen

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Abstract

Chronic toxoplasmosis, a foodborne illness primarily affecting immunocompromised people and pregnant women, remains untreatable. The causative parasite, Toxoplasma gondii, survives via tissue cysts within brain cells. To investigate nutrient acquisition by T. gondii in cyst development, the translocon-encoding genes GRA17 and GRA23 are proposed as possible drug targets, because they facilitate material transfer between host and parasite. The roles of GRA17 and GRA23 have been analyzed through physiological differences between knockout strains in growth and plaque assays. Preliminary results indicate both genes are crucial for parasite growth, suggesting that targeting them may be an effective strategy to treat chronic toxoplasmosis.

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
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Toxoplasma gondii Research Studies
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Abundance and viability of bryophyte spores found in honeybee pollen · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) (2025) | TGRS Research Map | TGRS