EW D-optimal Designs for Experiments with Mixed Factors

We characterize EW D-optimal designs as robust designs against unknown parameter values for experiments under a general parametric model with discrete and continuous factors. When a pilot study is available, we recommend sample-based EW D-optimal designs for subsequent experiments. Otherwise, we recommend EW D-optimal designs under a prior distribution for model parameters. We propose an EW ForLion algorithm for finding EW D-optimal designs with mixed factors, and justify that the designs found by our algorithm are EW D-optimal. To facilitate potential users in practice, we also develop a rounding algorithm that converts an approximate design with mixed factors to exact designs with prespecified grid points and the total number of experimental units. By applying our algorithms for real experiments under multinomial logistic models or generalized linear models, we show that our designs are highly efficient with respect to locally D-optimal designs and more robust against parameter value misspecifications.