A LSTM-Transformer Model for pulsation control of pVADs

Methods: A method of the pulsation for a pVAD is proposed (AP-pVAD Model). AP-pVAD Model consists of two parts: NPQ Model and LSTM-Transformer Model. (1)The NPQ Model determines the mathematical relationship between motor speed, pressure, and flow rate for the pVAD. (2)The Attention module of Transformer neural network is integrated into the LSTM neural network to form the new LSTM-Transformer Model to predict the pulsation time characteristic points for adjusting the motor speed of the pVAD. Results: The AP-pVAD Model is validated in three hydraulic experiments and an animal experiment. (1)The pressure provided by pVAD calculated with the NPQ Model has a maximum error of only 2.15 mmHg compared to the expected values. (2)The pulsation time characteristic points predicted by the LSTM-Transformer Model shows a maximum prediction error of 1.78ms, which is significantly lower than other methods. (3)The in-vivo test of pVAD in animal experiment has significant improvements in aortic pressure. Animals survive for over 27 hours after the initiation of pVAD operation. Conclusion: (1)For a given pVAD, motor speed has a linear relationship with pressure and a quadratic relationship with flow. (2)Deep learning can be used to predict pulsation characteristic time points, with the LSTM-Transformer Model demonstrating minimal prediction error and better robust performance under conditions of limited dataset sizes, elevated noise levels, and diverse hyperparameter combinations, demonstrating its feasibility and effectiveness.