Approximate Hamilton-Jacobi Reachability Analysis for a Class of Two-Timescale Systems, with Application to Biological Models

Hamilton-Jacobi reachability (HJR) is an exciting framework used for control of safety-critical systems with nonlinear and possibly uncertain dynamics. However, HJR suffers from the curse of dimensionality, with computation times growing exponentially in the dimension of the system state. Many autonomous and controlled systems involve dynamics that evolve on multiple timescales, and for these systems, singular perturbation methods can be used for model reduction. However, such methods are more challenging to apply in HJR due to the presence of an underlying differential game. In this work, we leverage prior work on singularly perturbed differential games to identify a class of systems which can be readily reduced, and we relate these results to the quantities of interest in HJR. We demonstrate the utility of our results on two examples involving biological systems, where dynamics fitting the identified class are frequently encountered.