Differential Diagnosis of the Disease in the Skeletal Remains of an 11-12-Year-Old Child from the Second Half of the 15th to the First Half of the 16th Century Necropolis of Vologda

Introduction. Studying ancient pathologies is a significant direction in modern scientific discourse, requiring the application of differential diagnostic methods for accurate data interpretation. Despite the complexity of such analyses, the data obtained enable us to gather reliable historical information about both past populations and individuals. This study presents an analysis of pathologies in an individual from the Vologda necropolis. Objective of the Study: Conduct a differential diagnosis of disease in an 11-12-year-old adolescent from the Vologda necropolis of the second half of the 15th to the first half of the 16th centuries. Materials and Methods. The individual studied was found during excavations in Vologda (Leningradskaya St., No. 12). The remains belonged to an adolescent aged 11-12 years. The study included a macroscopic assessment comprising visual inspection, determination of skeletal preservation and completeness, photographic documentation of the remains, and radiographic analysis of the affected bones. Results. The remains exhibited lesions in the iliac and ischial bones, ribs, vertebrae, skull bones, and scapulae. Manifestations were observed in bones with a significant proportion of cancellous tissue. Pathological changes were characterized by a combination of proliferative and destructive alterations. Radiographic analysis of the skull revealed a decrease in bone X-ray density, manifested as increased porosity. An area with decreased X-ray density resembling a 'cold abscess' was also identified in the iliac bones. However, distinct boundaries, which are a key feature of this pathological condition, are absent. Discussion. Among the most likely alternative diagnoses are brucellosis, tuberculosis infection, and malignant processes. These diseases are integrated into the differential diagnosis due to the combination of proliferative and destructive changes observed in the bone tissue. Conclusion. The analysis of diagnostic criteria and radiographic data suggests the presence of an oncological process. However, signs of periostitis on the ribs and evidence of meningitis on the endocranial surface may indicate chronic inflammation caused by infection. © 2025. This work is licensed under a CC BY 4.0 license