Glomerulonefriti acute: tre facce della stessa medaglia

The phenotypic variability of a single pathology complicates the diagnostic and therapeutic approaches, particularly for its more complex and less common forms. The paper describes three clinical cases of post-infectious glomerulonephritis, all presenting with macrohaematuria but evolving with different outcomes, ranging from clinical-laboratory findings to varying therapeutic management, including supportive therapies and the use of immunosuppressive treatments. Although acute post-infectious glomerulonephritis is typically a self-limiting condition, the third clinical case presented with rapidly progressive renal failure accompanied by a sudden clinical deterioration, requiring both haemodialysis and immunosuppressive therapy. The discussion of these three clinical cases - different sides of the same medal - aims to emphasise the extreme phenotypic variability of a single disease and the importance of early diagnostic and therapeutic evaluation.