HUWE1 and Its Role in Gametogenesis: A Critical Regulatory Nexus

HUWE1 is an Ubiquitin ligase found in the HECT domain involved in spermatogenesis, many other cellular processes. The current study aims to elucidate the function of HUWE1 in the processes of oogenesis and spermatogenesis. In males, it controls sperm development and meiosis, while in females, the enzyme is responsible for oocyte maturation, meiosis, and embryo development. It is located in ovaries and testis in both females and males respectively. The vital role was validated by different animal model studies on mice through knockout and knockdown of HUWE1. These findings indicated that the deletion of HUWE1 resulted in infertility in both sexes, thereby proving its significance in gametogenesis. Based on the findings, it is concluded that, that deletion or dysfunction of HUWE1 could lead to defective spermatogenesis and oogenesis, resulting in infertility. Keywords: Spermatogenesis, Oogenesis, HUWE1, infertility, animal models