Magnesium Glycinate

Abstract Magnesium glycinate is a bioavailable chelated form of magnesium that plays a key role in neurochemical balance and stress regulation. This article reviews its mechanisms in modulating GABAergic activity, supporting serotonin synthesis, and attenuating HPA axis hyperactivity. Evidence from clinical and preclinical studies suggests that magnesium glycinate can alleviate symptoms of depression, anxiety, and insomnia, while enhancing cognitive performance under high-stress conditions. Its superior absorption profile and low gastrointestinal side effects make it a preferred form for long-term supplementation. This review also outlines synergistic effects when combined with amino acids, adaptogens, and B vitamins, and discusses optimal dosing and safety considerations for various populations.