Amorphous Solid Dispersions: An Emerging Approach for Improving Solubility and oral Bioavailability of Poorly Water-Soluble Drugs

Drugs that are poorly soluble in water can have their oral bioavailability and solubility increased with the use of amorphous solid dispersions (ASDs). Numerous techniques have been used to create ASDs, and new ones are always being created. This report includes an updated explanation of the manufacturing methods used to create ASDs. Physical stability has been studied in relation to downstream processing, formulation, equipment, and process parameters because it is a critical quality trait for ASDs. Selection strategies are proposed to identify suitable manufacturing methods that could aid in producing ASDs with sufficient physical stability.