Anti-burn Activity of Syzygium Cumini

Introduction: Burns are one of the most common and devastating forms of trauma. Burns are damage to the skin or injury to flesh caused by heat, electricity, chemicals, light, radiation or friction. Materials: Syzygium cumini was collected from cultivator, chopped and dried in the shade. Later was size reduced, extracted with ethanol, the extract obtained was dried and used for preclinical studies. 24 albino male Sprague Dawley rats weighing between 120-150grams were selected. Method: The heating nail method was used to produce burn wounds to anesthetized animals after shaving the fur. First degree burns were induced using heated nail of surface area 2cm2 with contact time of 20sec. The nail was preheated in 100°C boiling water for 10 mins and then was applied perpendicularly to the shaved skin for a period of 20sec. After formation of burn wounds, the formulations were repeatedly applied (one application every day) to the burned areas for 10 days. The tensile strength of the wound is measured as parameter of evaluation. Result: Syzygium cumini was found to have antioxidant activity and antiburn activity with P<0.05 and rejected null hypothesis. It also showed quick burn healing, improving the tensile strength of healed wounds. This anti-burn wound healing property is due to the presence of suitable phytochemical constituents. Conclusion: Syzygium cumini has significant antiburn potential and antioxidant potential. Futher studies can be performed on isolating the fraction to identify the main active ingredient responsible for its potential. Keywords Antiburn activity, Burns, Syzygium cumini, Wound healing, Kala jamun.