New Onset of Diabetes Mellitus After Renal Transplantation

Objective: Diabetes after transplantation is associated with poor graft function as well as increased risks of infection and death after renal transplantation. The term “new-onset diabetes mellitus” (NODM) is used exclusively for the development of diabetes after transplantation. Significance: This paper reported the incidence of NODAT that greatly depends on the length of follow-up, diagnostic criteria, and immunosuppression regimen. The true incremental incidence of diabetes occurs mainly during the first 6 months post transplantation, when patients are treated with high doses of immunosuppression. Conclusion: New-onset diabetes after transplantation is an important comorbidity in renal transplant recipients. The condition is common, and likely to be caused by a number of pre- and post-transplant-related factors, including pre- and post-transplant therapy, and patient-related risk factors for metabolic problems. The onset of hyperglycaemia after renal transplant appears to lead to increased risks, and these need careful management.