EFFECTS OF TANNIC ACID TREATMENTS ON ETHANOL-INDUCED PREFRONTAL CORTEX TOXICITY: A NEUROBEHAVIOURAL INVESTIGATION

Abstract: Background: Animal models have demonstrated brain damage upon ethanol intoxication. Tannic acid (TA) demonstrates various medicinal capabilities including neuroprotective potentials. Aim: To investigate the neurobehavioral effects of TA treatments following ethanol-induced prefrontal cortex toxicity. Methodology: Thirty six (36) adult male wistar rats (160g-240g) were assigned into six (6) groups (A to F) of 6 rats each. Group “A” (untreated negative control) received daily doses of distilled water at 6ml/kg/bwt while Group “B” (alcohol control group) received daily doses of 6g/kg/bwt of 40% ethanol only. Group “C, D and E” received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 200mg/kg/bwt, 100mg/kg/bwt and 50mg/kg/bwt of TA respectively. Group “F” (positive control group) received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 335mg/kg/bwt of Vitamin-E. All treatments were oral and lasted 14 days. Neurobehavioural investigation was conducted on day 15 via an Open field test (OFT), an Elevated plus maze test (EPM), and a Y-maze test respectively. Following statistical analysis, using one-way ANOVA, p–value≤0.05 was considered as statistically significant. Result: No statistically significant difference was recorded in both time spent in the center and in the periphery during the OFT. No statistically significant difference was recorded in the number of open and closed arm entries in the EPM. No statistically significant difference was recorded in mean percentage alternation between the treatment and control groups in the Y-maze Test. Conclusion: TA did not mitigate or worsen the neurobehavioural effects of ethanol-induced prefrontal cortex toxicity, maintaining the insights on its neuroprotective potentials. Keywords: Tannic acid, Neurobehavioral effects, Prefrontal cortex, Wistar rats. Title: EFFECTS OF TANNIC ACID TREATMENTS ON ETHANOL-INDUCED PREFRONTAL CORTEX TOXICITY: A NEUROBEHAVIOURAL INVESTIGATION Author: Christian Chiemeka Ozor, Chike Anibeze International Journal of Recent Research in Life Sciences (IJRRLS) ISSN 2349-7823 Vol. 11, Issue 4, October 2024 - December 2024 Page No: 34-40 Paper Publications Website: www.paperpublications.org Published Date: 24-December-2024 DOI: https://doi.org/10.5281/zenodo.14552691 Paper Download Link (Source) https://www.paperpublications.org/upload/book/EFFECTS%20OF%20TANNIC%20ACID%20TREATMENTS-24122024-6.pdf