Formulation and Evaluation of Cream Containing Extracts of Cassia fistula and Lavandula bipinnata: In Vitro and Docking Study of Phytochemicals

This research centers on formulating and assessing a herbal-based cream using methanolic extracts of Cassia fistula and Lavandula bipinnata, well-known for their antimicrobial, antioxidant, and anti-inflammatory properties. The extracts were obtained via Soxhlet extraction and incorporated into an oil-in-water (O/W) cream base. The formulation was evaluated for physicochemical properties such as pH, viscosity, Spreadability, and stability under accelerated conditions. Antimicrobial activity was tested against common skin pathogens, and molecular docking studies were performed to predict the interaction of phytoconstituents with microbial protein targets. The results showed the cream to be stable, safe and effective in combating microbial infections. Hence, the formulated herbal cream presents a promising natural alternative for dermatological applications.