Formulation And Evaluation of Pellets

The present study focuses on the formulation and evaluation of Esomeprazole-coated sustained release pellets using various polymers in different ratios. Esomeprazole, a proton pump inhibitor, is acid-labile and requires protection from gastric acid for effective intestinal absorption. In this research, non-pareil (NP) seeds were prepared using the extrusion-spheronization process and subsequently coated with Esomeprazole and sustained release polymers through the pan coating method. Various polymer ratios were applied to assess their effect on drug release behavior. The formulated pellets were evaluated for physical properties such as size, flow properties, and friability, along with in-vitro drug release studies under simulated gastrointestinal conditions. The influence of different polymer types and coating levels on the drug release profile was systematically analyzed. The optimized formulation exhibited controlled and sustained drug release with improved stability compared to conventional dosage forms.