Microsponges: A Novel Drug Delivery For Dermatological Application

A microsponge's delivery system is a highly cross-linked, porous, polymeric microsphere system composed of porous microspheres capable of entrapping and releasing chemicals into the skin over time. This delivery system offers extended release, lower discomfort, better tolerance, and improved thermal, physical, and chemical stability. Microsponges are created using a variety of processes, such as suspension polymerization in a liquid-liquid system and emulsion systems. Microsponges can trap a variety of medications and can be utilized in cream, powder, gel, or lotion formulations. The delivery mechanism of microsponges solves the drawbacks of topical preparations, which include offensive odor, greasiness, and skin irritation, as well as their inability to enter the systemic circulation. Microsponge's formulations are compatible with the majority of vehicles and ingredients and stable throughout a pH range of 1 to 11. They are also stable at temperatures as high as 130°C. The current review provides an overview of microsponge technology, including its synthesis, characterisation, benefits, assessment, and drug delivery system release mechanism. It also includes information on marketed products and the most recent findings about microsponges.