PS-1, PS-2 VA PS-3 POLIFENOLLARINING AORTA SILLIQ MUSKULI PREPARATIGA VAZORELAKSANT TA'SIRIDA SARKOPLAZMATIK RETIKULUM RIANODIN RETSEPTORINING ISHTROKININI BAHOLASH

Tadqiqotlarda Euphorbia farnchetii turiga mansub bo‘lgan o‘simliklardan ajratib olingan 1-O-galloil-6-O-bisgalloil-2,4-valoneil-β-D-glyukoza (PS-1), 1-O-galloil-2,3-geksagidroksidifenoil-4,6-valoneil-β-D-glyukoza (PS-2) va 1,4,6 tri-O-galloil-2,3-valoneil-β-D-glyukoza (PS-3) polifenol birikmalarining izometrik sharoitda kalamush aorta qon-tomir silliq muskuli preparati qisqarish faolligiga vazorelaksant ta’sirini ta’minlanishida sarkoplazmatik retikulum rianodin retseptorining ishtroki baholangan. Tajribalarda tekshirilayotgan polifenollarning aorta silliq muskuli qisqarishlariga vazorelaksant ta’siri sarkoplazmatik retikulum (SR)ning rianodin retseptori (RyR) orqali chiquvchi Ca2+-ionlarini kamayishi aorta silliq muskuli hujayralari sitozolida Ca2+-ionlarini kamayishiga olib kelgan va buning natijasida qisqarish kuchini kamayishi kuzatilgan.