Pharmacological Values of Benzodiazepam: A Potent Sedative and Anticovulsant

Benzodiazepam, also known as 9-chloro-2-methyl-6-phenyl-2,5-diazabicyclo, are structurally and pharmacologically closely related. It works well for many people whose epilepsy has not responded to other antiepileptic medications and has a wide range of action against the different forms of epilepsy. Its main use are in status epilepticus, where intravenous Benzodiazepam may be used as a first-choice medication instead of diazepam, and in childhood small motor seizures, especially petit mal absences, Lennox-Gastaut syndrome, and infantile spasms. In psychomotor and myoclonic epilepsies, Benzodiazepam is also at least as successful as existing treatments. However, it is unlikely to take the place of phenytoin and barbiturates in the treatment of grand mal or focal motor seizures, unless the patient is not responding to normal treatment. Benzodiazepam's early effectiveness may be followed by a loss of effect; however, by temporarily stopping and restarting treatment, the benefit can frequently be recovered, at least initially. There are frequently side effects from Benzodiazepam. In addition to the less common occurrences of ataxia, dystonia, hypotonia, and hyperactivity, the majority of patients suffer weariness and drowsiness, which are common causes of withdrawal. These side effects are minimized by introducing the medication gradually over a period of two to four weeks, and they typically go away with continuing therapy. Children and newborns may experience hypersalivation and excessive bronchial secretion.