A Study on Coadministration of Different Doses of Phenylephrine with Oxytocin Effect in Oxytocin-Induced Hypotension in Caesarean Section Under Spinal Anaesthesia

Introduction: Postpartum hemorrhage (PPH) from uterine atony is a leading cause of maternal mortality. Oxytocin, while effective in reducing PPH, can cause hypotension during caesarean sections under spinal anesthesia. This study investigates the optimal dose of phenylephrine, an α1-adrenergic agonist, to counteract oxytocin-induced hypotension, enhancing maternal hemodynamic stability. Methods: This prospective randomized study at Government Medical College, Rajamahendrawaram included parturients for caesarean sections. Patients were randomized to receive oxytocin with either 50 mcg or 75 mcg phenylephrine infusions. Baseline measurements, subarachnoid block, and postoperative monitoring were conducted. Uterine tone, neonatal APGAR scores, and adverse effects were recorded. Results: Total 80 members were included, 50 each group. Statistically there was no significance difference between the groups in age, mean height, mean weight, duration of SC, baby extraction time. Whereas there was significant difference between groups in hypotension and mean blood parameters. Conclusion: This study suggests that phenylephrine, when co-administered with oxytocin during caesarean sections, effectively stabilizes maternal hemodynamics, reducing hypotension without significant adverse effects. Optimal dosing of phenylephrine can enhance maternal safety by maintaining blood pressure and uterine tone, providing a valuable protocol for managing oxytocin-induced hypotension in obstetric anesthesia.