IMPORTANT ROLE PLAYS OF GABA AND ITS TYPES IN ALZHEIMER'S DISEASE: A REVIEW

ABSTRACT Gamma-Aminobutyric Acid (GABA) and its many receptor types have a complex function in Alzheimer's disease (AD), as this thorough analysis explores. An essential inhibitory neurotransmitter, GABA, has a variety of functions in controlling brain activity and cognitive functions. Review critically examines the existing literature on GABAergic alterations in AD, discussing how dysfunction in GABA signaling pathways may contribute to disease etiology and progression. Special attention is given to the diverse GABA receptor subtypes and their potential modulatory effects in AD pathology, shedding light on the complex interplay between neurotransmission and neurodegeneration. The insights garnered from this review emphasize how crucial it is to conduct further study in order to fully understand GABAergic pathways for possible treatment approaches. Alzheimer's disease is a progressive neurological disease that is now incurable. Aβ-plaques and NF-tangles are its defining features. GABAis a neurotransmitter that inhibits neurons in cerebral cortex, hippocampus other parts of brain. An inhibitory neurotransmitter called GABA is extensively dispersed throughout the brain's hippocampus, thalamus, basal ganglia, and core. Its primary purpose is to suppress or lessen neuronal activity, which aids in fever, tension, anxiety, relaxation. In pre-synaptic neurons, glutamate is converted to GABA using an enzyme named glutamate decarboxylase and vitamin B6.