Formulation and Evaluation of Voriconazole Solid Lipid Nanoparticles as a Shampoo

Voriconazole, a widely used antifungal agent, exhibits hydrophilic properties and is effective in managing fungal infections. However, its oral and parental administration is often associated with significant side effects, including hepatobiliary disorders like hyperbilirubinemia, as reported in various clinical trials. These adverse effects limit its therapeutic potential and necessitate alternative drug delivery strategies. Objective: This study focuses on the development of solid lipid nanoparticles for the topical delivery of Voriconazole in the form of a medicated shampoo for scalp infections. Solid lipid nanoparticles were selected due to their reported advantages, such as enhanced affinity for the stratum corneum and improved bioavailability. The transition from oral to topical delivery aims to minimize systemic side effects while maintaining therapeutic efficacy. Additionally, functional modifications in the formulation were incorporated to optimize drug performance. This work highlights the potential of Voriconazole loaded solid lipid nanoparticles as a promising approach for targeted antifungal therapy, addressing the challenges of conventional administration methods and reducing associated side effects.