In-Situ Gel of Statins for Periodontitis Diseases

Periodontitis is a chronic inflammatory disease affecting the teeth' supporting structure, leading to tissue destruction and loss of teeth. Conventional treatment strategies like mechanical debridement and systemic antibiotic therapy have limitations due to bacterial resistance and patient compliance challenges. Therefore, in situ gels have emerged as a promising local drug delivery system for effectively managing periodontitis. This review explores the role of HMG-CoA inhibitors (statins), in in situ gel formulations for periodontal therapy. Statins exhibit pleiotropic effects, including anti-inflammatory and bone-regenerative properties, which make them an attractive adjunct in periodontitis treatment. The review discusses various fabrication methods for in-situ gels, including temperature-sensitive, pH-responsive, and ion-activated systems that sustain and control drug release. Compared to conventional drug delivery methods, in-situ gels enhance drug retention within the periodontal pocket, improve therapeutic efficacy, and minimize systemic side effects. This review underscores the potential of atorvastatin-loaded in situ gels as an innovative and effective approach for managing periodontitis, paving the way for future advancements in periodontal therapy.