FORMULATION AND EVALUATION OF MICROSPHERES OF NIFEDIPINE

The aim of the study was to prepare Nifedipine microspheres using Solvent evaporation method using different polymer ratio. FT-IR studies revealed that there was no chemical interaction between the drug and polymer. The average particle size of the optimized formulation was found to be 166 μm. The in-vitro release behavior from all the Nifedipine microspheres was found to be peppas drug release kinetics and produced a sustained release over a period of 12 hours with better entrapment efficiency. Key words: Nifedipine, Eudragit, Carbopol 934p, HPMC, Solvent evaporation method and microspheres.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-12-30
DOI
https://doi.org/10.5281/zenodo.14577858
Primary Topic
Advanced Drug Delivery Systems
Type
article
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article

FORMULATION AND EVALUATION OF MICROSPHERES OF NIFEDIPINE

Zenodo (CERN European Organization for Nuclear Research)
Advanced Drug Delivery Systems
article

FORMULATION AND EVALUATION OF MICROSPHERES OF NIFEDIPINE

article en

Abstract

The aim of the study was to prepare Nifedipine microspheres using Solvent evaporation method using different polymer ratio. FT-IR studies revealed that there was no chemical interaction between the drug and polymer. The average particle size of the optimized formulation was found to be 166 μm. The in-vitro release behavior from all the Nifedipine microspheres was found to be peppas drug release kinetics and produced a sustained release over a period of 12 hours with better entrapment efficiency. Key words: Nifedipine, Eudragit, Carbopol 934p, HPMC, Solvent evaporation method and microspheres.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 60%
Advanced Drug Delivery Systems
DOIOpen Access PDFOpenAlex
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FORMULATION AND EVALUATION OF MICROSPHERES OF NIFEDIPINE · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS