Tuberculous Meningitis: A Detailed Review

Abstract Tuberculous meningitis (TBM) is a medical emergency. This is the most severe form of tuberculosis (TB). Appropriate therapy and early diagnosis are critical to the result. If there is a high level of clinical suspicion, empirical antituberculosis therapy ought to be initiated. HIV testing must be performed on every patient. Numerous antituberculosis medications have poor penetration into the cerebrospinal fluid, and the selection of these medications is based on the pulmonary TB regimen. To guide pharmacological therapy in TBM, more evidence is needed. The host's genotype may affect the response to steroids, which should be given as an adjuvant therapy. Complications include stroke, hyponatremia, and hydrocephalus should be actively monitored.