A Review on "Advance Solubility Enhancement Techniques": Significant Strategy in Development of Formulation

In pharmaceutical formulation, solubility is essential parameter because it directly impacts the bioavailability, effectiveness and therapeutic response of drugs. Many researchers are facing obstacles in the formulation and development due to poor aqueous solubility of drug, especially for Class II and IV medications under its Biopharmaceutical Classification System (BCS). Several research papers and articles were reviewed during study for improving solubility, including hydrotropy, inclusion complexation, micronization, particle size reduction, co-solvency, pH regulation, and supercritical fluids. New methods including co-precipitation, lyophilisation, and electrospinning are also examined. The benefits, difficulties, and uses of solubility enhancement techniques are also covered in detail in this article. This review article has mainly focused on by comprehending and utilisin solubility enhancement techniques in development pharmaceutical formulations, which increases therapeutic efficacy of formulation which is responsible for sustainability of product in market.